Hybrid supraparticles for combined MPI and magnetic hyperthermia

Combining magnetic particle imaging (MPI) with magnetic hyperthermia in a single location opens new effective theranostic applications, e.g. in targeted cancer therapy. We present the utilization of hybrid supraparticles containing two nanoparticle species to create particles with optimized magnetic properties for both technologies. For this, ferromagnetic particles, which are known for their good performance for hyperthermia are combined with superparamagnetic particles, which are very well suitable for MPI. The supraparticles are characterized regarding their MPS spectra and heating power during magnetic hyperthermia. Additionally, first experiments demonstrate the feasibility of the approach also for imaging. The results represent a proof-of-concept for the supraparticle approach, which will facilitate the optimization of particle properties for both technnologies at the same time.