2025
Note
Title

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Abstract
Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.
Author(s)
Benvenisty, Nissim
Hebrew University of Jerusalem
Draper, Jonathan S.
Stem Cell Network
Gokhale, Paul J.
The University of Sheffield
Healy, Lyn E.
The Francis Crick Institute
Hewitt, Zöe A.
The University of Sheffield
Hursh, Deborah
LLC
Hodgson, Adam
The University of Sheffield
Ludwig, Tenneille E.
WiCell Research Institute
Mah, Nancy Lynne  orcid-logo
Fraunhofer-Institut für Biomedizinische Technik IBMT  
McClelland, Sarah Elizabeth
Barts and The London School of Medicine and Dentistry
Mennecozzi, Milena
European Commission Joint Research Centre
Merkle, Florian T.
University of Cambridge
Mountford, Joanne C.
Scottish National Blood Transfusion Service
Pera, Martin F.
The Jackson Laboratory
Prigione, A.
Universitätsklinikum Düsseldorf
Rodríguez, Tristan Argeo
National Heart and Lung Institute
Rossi, Andrea
Leibniz Research Institute for Environmental Medicine
Rouhani, Foad J.
The Francis Crick Institute
Saeb-Parsy, Kourosh
Department of Surgery
Selfa Aspiroz, Lucia
European Commission Joint Research Centre
Shakiba, Nika
The University of British Columbia
Spits, Claudia
Faculteit Geneeskunde en Farmacie
Tonge, Peter Dennis
Babraham Research Campus
Barbaric, Ivana
The University of Sheffield
Journal
DOI
Language
English