Biomaterialien - Nachbildung der Stammzellnische in Bioreaktoren

The generation of high-quality human pluripotent stem cells and their derivatives requires growth surfaces imitating the natural micro-environment. Stiff plastic surfaces with protein coatings are not an optimal stem cell niche and adjustable growth surfaces are needed to meet the cell-specific requirements. Alginate hydrogels are versatile biomaterials in stem cell processes since they can be integrated in all fundament cell workflows not only as planar surface but also as microcarrier cultures in suspension bioreactors.