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2022
Presentation
Titel
AIDPATH - Modular Approach to AI-Enabled CAR-T Cell Manufacturing
Titel Supplements
Presentation held at International Forum on Cell Manufacturing & Engineering, October 18, 2022, Berlin
Abstract
CAR-T Manufacturing suffers from labor intensive manufacturing, biological variability of patient material while inflexible production protocols are employed. To improve the availability of CAR-T therapies to patient the AIDPATH EU-Project aims to develop build and test a modular decentralized manufacturing system for CAR-T therapy. Automating using a closed handling approach allows for parallelization while the modularity enables broad technological compatibility. Automated sampling for in-line quality control collects large amount of data on the cell samples which are fed in an AI-digital twin of the CAR-T product to support and adapt the manufacturing process. Automating the manufac-turing process and accounting for biological variability is the key to optimize CAR-T cell production.
Funder
Europäische Union
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