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  4. In vitro study of mouse fibroblast tumor cells with TNF coated and Alexa488 marked silica nanoparticles with an endoscopic device for real time cancer visualization
 
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2009
  • Konferenzbeitrag

Titel

In vitro study of mouse fibroblast tumor cells with TNF coated and Alexa488 marked silica nanoparticles with an endoscopic device for real time cancer visualization

Abstract
Tumor resection done by minimally invasive procedure owns the challenge of a fast and reliable differentiation between healthy and tumorous tissue. We aim at investigating and developing a method for an intraoperative visualization of tumor cells with functionalized nanoparticles. The goal is to use this technique for the intraoperative use. Our so-called biohybrid systems consist of nanoparticies that are produced by Stober synthesis and coupled with bio active proteins. Such biomimetic nanostructures are capable of imitating the effects of membrane-bound cytokines, which bind to tumor cells for labeling them. A flexible and modular test environment has been developed to evaluate the spraying properties of the particles and to study tissue probes. It enables a fast investigation of different particle configurations and spraying parameters like pressure, spray volume, nozzle geometry, etc.
Author(s)
Herz, Marion
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
Rank, Andreas
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
Tovar, Günter E.M.
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
Hirth, Thomas
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
Kaltenbacher, Dominik
Stallkamp, Jan
Weber, Achim
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
Hauptwerk
Active polymers
Konferenz
Symposium NN "Active Polymers" 2009
Materials Research Society (Spring Meeting) 2009
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DOI
10.1557/PROC-1190-NN11-23
Language
Englisch
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Tags
  • biotechnology

  • Gewebe

  • Laboratory automation...

  • Operation

  • tumor diagnostic

  • Tumordiagnostik

  • Nanopartikel

  • Biotechnologie

  • Laboratorium

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