Monolithic silicon optoelectronic transducers and elastomeric fluidic modules for bio-spotting and bio-assay experiments

A monolithic silicon optoelectronic transducer for protein sensing is presented. The device is based on monolithic silicon optocouplers properly bio-functionalized so that signal transduction is induced by the optical coupling deduction due to biomolecular binding. Microfluidic modules made of PDMS are also employed for immobilization of biomolecules onto the optocouplers and sample application. Bioassay results concerning simultaneous real-time monitoring of binding reactions between two different protein analytes and their counterparts immobilized onto adjacent optocouplers are presented.