Improved microfluidic devices and methods to obtain them

A polymeric device, in particular microfluidic device (100), cell culture system or membrane comprising a system (20) of microchannels (25), wells and/or pores, in a polymeric device (10), wherein at least a part of the surface area of the microchannels (25) is formed by an absorption barrier layer system, wherein the absorption barrier layer system comprises at least one polymeric interface layer (40) and at least one barrier coating layer (50).