Verfahren zur Herstellung autonom kontrahierender Herzmuskelzellen aus adulten Stammzellen, insbesondere humanen adulten Stammzellen

Es wird ein Verfahren zur Bildung von autonom kontrahierenden Herzmuskelzellen durch Kultivierung und Differenzierung von Stammzellen beschrieben, die aus differenziertem exokrinen Druesengewebe eines Organismus gewonnen wurden. Es werden auch verschiedene Anwendungen der Herzmuskelzellen, insbesondere in der Regenerationsmedizin, beschrieben.

DE 102006003996 A1 UPAB: 20070911 NOVELTY - Method for the formation of heart muscle cells (cardiomyocytes), comprises culturing and differentiating stem cells, which are obtained from differentiated exocrine gland tissue of an organism. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for: (1) an isolated heart muscle cell capable of autonomous contraction, which is formed by the above procedure and isolated from the differentiated exocrine gland tissue of an organism; (2) a cell composition comprises a multiple number of heart muscle cells; (3) a material composition comprising the cell or the cell composition and a carrier or coating material; and (4) a bidirectionally transformable stem cell patch (BTS), comprising adult stem cells, which were isolated from exocrine gland tissue of an organism; a porous matrix for the uptake of the cells; and a broad contact surface of the BTS for the placement on a broad surface of wounded myocardial tissue. ACTIVITY - Cardiant. MECHANISM OF ACTION - Cell therapy. USE - The heart muscle cells are useful in medical application, preferably in regeneration of medicine; in regeneration of injured or damaged myocardium; and for transplantation or in medical device (all claimed).