• English
  • Deutsch
  • Log In
    Password Login
    or
  • Research Outputs
  • Projects
  • Researchers
  • Institutes
  • Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Artikel
  4. Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
 
  • Details
  • Full
Options
2021
Journal Article
Titel

Immunocompetent cancer-on-chip models to assess immuno-oncology therapy

Abstract
The advances in cancer immunotherapy come with several obstacles, limiting its widespread use and benefits so far only to a small subset of patients. One of the underlying challenges remains to be the lack of representative nonclinical models that translate to human immunity and are able to predict clinical efficacy and safety outcomes. In recent years, immunocompetent Cancer-on-Chip models emerge as an alternative human-based platform that enables the integration and manipulation of complex tumor microenvironment. In this review, we discuss novel opportunities offered by Cancer-on-Chip models to advance (mechanistic) immuno-oncology research, ranging from design flexibility to multimodal analysis approaches. We then exemplify their (potential) applications for the research and development of adoptive cell therapy, immune checkpoint therapy, cytokine therapy, oncolytic virus, and cancer vaccines.
Author(s)
Maulana, T.I.
Kromidas, E.
Wallstabe, L.
Cipriano, M.
Alb, M.
Zaupa, C.
Hudecek, M.
Fogal, B.
Loskill, P.
Zeitschrift
Advanced drug delivery reviews
Thumbnail Image
DOI
10.1016/j.addr.2021.03.015
Externer Link
Externer Link
Language
English
google-scholar
Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Send Feedback
© 2022