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  4. Towards a 21st-century roadmap for biomedical research and drug discovery: Consensus report and recommendations
 
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2017
Journal Article
Titel

Towards a 21st-century roadmap for biomedical research and drug discovery: Consensus report and recommendations

Abstract
Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and non-governmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.
Author(s)
Langley, G.R.
Adcock, I.M.
Busquet, F.
Crofton, K.M.
Csernok, E.
Giese, C.
Heinonen, T.
Herrmann, K.
Hofmann-Apitius, M.
Landesmann, B.
Marshall, L.J.
McIvor, E.
Muotri, A.R.
Noor, F.
Schutte, K.
Seidle, T.
Stolpe, A. van de
Esch, H. van
Willett, C.
Woszczek, G.
Zeitschrift
Drug Discovery Today
Project(s)
NOTOX
Funder
European Commission EC
Thumbnail Image
DOI
10.1016/j.drudis.2016.10.011
Language
English
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