System integration of a silicone-encapsulated glucose monitor implant

An intelligent sensor implant for continuous glucose monitoring is presented as intended for use in the human interstitial. The sensor operates by the principle of affinity viscosimetry, by which glucose concentrations are determined with a microelectromechanical system (MEMS) measuring the glucose-dependent viscosity of a concanavalinA-dextran assay. Data transmission is performed in the 403MHz band as approved for medical implant communication services (MICS). The sensor system is encapsulated in silicone to enable a sufficient hermiticity for time spans of weeks and months. In vitro testing revealed no corrosion of system components for a period of months.