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  4. Microdevices for separation, accumulation, and analysis of biological micro- and nanoparticles
 
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2003
Journal Article
Title

Microdevices for separation, accumulation, and analysis of biological micro- and nanoparticles

Abstract
Microfabrication and performance of a novel microsystem for separation, accumulation and analysis of biological micro- and nanoparticles is reported. Versatile chip functions based on dielectrophoresis and microfluidics were integrated to isolate particles from complex sample solutions such as serum. A bead-based assay for virus detection is proposed. Separation of micro-and sub-m beads employing dielectrophoretic deflector and bandpass structures is demonstrated. Individual antibody coated beads with hepatitis A virus bound to their surface were trapped by negative dielectrophoresis in a field cage and analysed by fluorescence microscopy.
Author(s)
Kentsch, J.
Dürr, M.
Schnelle, T.
Gradl, G.
Müller, T.
Jäger, M.
Normann, A.
Stelzle, M.
Journal
IEE proceedings / Nanobiotechnology  
DOI
10.1049/ip-nbt:20031127
Language
English
Fraunhofer-Institut für Biomedizinische Technik IBMT  
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