Practical considerations for pharmaceutical antibody production in different crop systems
Abstract
The potential of plant cells to produce functional recombinant antibodies has been demonstrated in a number of different plant systems. We present a comparative study of a well-defined target protein, a single chain Fv antibody, in different transgenic crop species and cultured tissues. The effect of different regulatory elements and signals for subcellular targeting are considered. Practical considerations for the choice of a particular crop system, such as yield, storage, distribution and containment properties are discussed.
