Immediate Drop on Demand Technology (I-DOT)

The handling and dosing of cells is the most critical step in the microfabrication of 3D-cell-based assay systems for screening and toxicity testing applications. The use of robotic workstations for liquid handling has increased enormously over the last decades, in order to meet the requirements for high accuracy and high throughput of current bioanalytics. The immediate drop on demand technology (I-DOT) overcomes the challenge of dispensing cells in a small volume precisely and with low shear stress. I-DOT provides a fast and flexible non-contact liquid handling system enabling dispensing cells and liquid without the risk of cross-contamination to a precise volume even in nanoliter range.