Model-based design of experiments using a flowsheet-simulator

The quality of process optimization depends on model parameters. The use of operating data from mini-, pilot or production plants can help to improve model agreement with operation. To support the design of experiments (DoE) in plants with many operability limitations a model-based DoE was implemented into a flowsheet simulator. In this contribution, the implementation of the method is described and its use for the identification of kinetics is demonstrated for a cumene process.