Detektion von menschlichen Immunzellen in der humanisierten Maus. Biomedizin

Animal models are a useful tool to study pathomechanisms and therapeutic targets in biomedical research. In the last decade the investigation of different humanized mouse models became important in research. The existence of human immune cells in immunodeficient mice allows the bridging between rodent model and human immune system. The method of choice to characterize these humanized mice is flow cytometry. Here, we explain facts about human immune cells in mice and show how to detect them.