Human immune system in a microtiter plate

Pattern recognition receptors (PRRs) are the first defense line of the innate immune system. In the last years PRRs had been studied in different ways resulting in a lot of new insights. However, it was not possible to investigate individual combinations of PRRs and their specific ligands because of the complex network in immune signaling. A cell-based assay developed at Fraunhofer IGB allows a direct way to detect the activity of individual human PRR-receptors in a highly specific way.