High-throughput manufacturing of 3D human epidermal models

Human epidermal models are routinely used in an increasing number of skin irritation and toxicity testing following OECD guidelines. However, only a fraction of the current demand can be met by producing these models manually. The high-throughput manufacturing of such tissue models requires a standardized and automated production infrastructure. Thus the objective of the »Tissue Factory« project was to build a prototype machine for the production of in vitro test models. The aim was to reduce the production costs, standardize the manufacturing methods, and allow the production to run nonstop year round.