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  4. Immobilization of detonation nanodiamonds on macroscopic surfaces
 
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2019
Journal Article
Title

Immobilization of detonation nanodiamonds on macroscopic surfaces

Abstract
Detonation nanodiamonds (NDs) are a novel class of carbon-based nanomaterials, and have received a great deal of attention in biomedical applications, due to their high biocompatibility, facile surface functionalization, and commercialized synthetic fabrication. We were able to transfer the NDs from large-size agglomerate suspensions to homogenous coatings. ND suspensions have been used in various techniques to coat on commercially available substrates of pure Ti and Si. Scanning electron microscopy (SEM) imaging and nanoindentation show that the densest and strongest coating of NDs was generated when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide (EDC/NHS)-mediated coupling to macroscopic silanized surfaces. In the next step, the feasibility of DNA-mediated coupling of NDs on macroscopic surfaces is discussed using fluorescent microscopy and additional particle size distribution, as well as zeta potential measurements. This work compares different ND coating strategies and describes the straightforward technique of grafting single-stranded DNA onto carboxylated NDs via thioester bridges.
Author(s)
Balakin, Sascha  
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Dennison, Nicholas R.
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Klemmed, Benjamin
TU Dresden
Spohn, Juliane  
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Cuniberti, Gianaurelio
TU Dresden
Römhildt, Lotta
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Opitz, Jörg  
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Journal
Applied Sciences  
Open Access
DOI
10.3390/app9061064
Additional full text version
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Language
English
Fraunhofer-Institut für Keramische Technologien und Systeme IKTS  
Keyword(s)
  • detonation nanodiamond

  • bio-conjugation

  • de-agglomeration

  • fluorescent microscopy

  • nanoindentation

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