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  4. Biosensing platform combining label-free and labelled analysis using Bloch surface waves
 
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2015
Conference Paper
Titel

Biosensing platform combining label-free and labelled analysis using Bloch surface waves

Abstract
Bloch surface waves (BSW) propagating at the boundary of truncated photonic crystals (1D-PC) have emerged as an attractive approach for label-free sensing in plasmon-like sensor configurations. Due to the very low losses in such dielectric thin film stacks, BSW feature very low angular resonance widths compared to the surface plasmon resonance (SPR) case. Besides label-free operation, the large field enhancement and the absence of quenching allow utilizing BSW coupled fluorescence detection to additionally sense the presence of fluorescent labels. This approach can be adapted to the case of angularly resolved resonance detection, thus giving rise to a combined label-free / labelled biosensor platform. It features a parallel analysis of multiple spots arranged as a one-dimensional array inside a microfluidic channel of a disposable chip. Application of such a combined biosensing approach to the detection of the Angiopoietin-2 cancer biomarker in buffer solutions is reported.
Author(s)
Danz, Norbert
Fraunhofer-Institut fĂĽr Angewandte Optik und Feinmechanik IOF
Sinibaldi, Alberto
Univ Roma La Sapienza
Munzert, Peter
Fraunhofer-Institut fĂĽr Angewandte Optik und Feinmechanik IOF
Anopchenko, Aleksei
Univ Roma La Sapienza
Förster, Erik
Fraunhofer-Institut fĂĽr Angewandte Optik und Feinmechanik IOF
Schmieder, Stefan
Fraunhofer-Institut fĂĽr Werkstoff- und Strahltechnik IWS
Chandrawati, Rona
Imperial College London
Rizzo, Riccardo
Univ Roma La Sapienza
Heller, Rene
Radeberger Präzisions- Formen- und Werkzeugbau
Sonntag, Frank
Fraunhofer-Institut fĂĽr Werkstoff- und Strahltechnik IWS
Mascioletti, Alessandro
Labor S.r.l.
Rana, Subinoy
Imperial College London
Schubert, Thomas
Radeberger Präzisions- Formen- und Werkzeugbau
Stevens, Molly M.
Imperial College London
Michelotti, Francesco
Univ Roma La Sapienza
Hauptwerk
Optical Sensors 2015
Konferenz
Conference "Optical Sensors" 2015
Thumbnail Image
DOI
10.1117/12.2178444
Language
English
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Fraunhofer-Institut fĂĽr Angewandte Optik und Feinmechanik IOF
Fraunhofer-Institut fĂĽr Werkstoff- und Strahltechnik IWS
Tags
  • optical biosensors

  • Bloch surface waves

  • fluorescence and lumi...

  • photonic crystal

  • label-free optical se...

  • optical multilayer sy...

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