Impedance monitoring of virus-induced cytopathic effect in cells

This paper reports the theoretical and experimental investigation about the impedance monitoring of green monkey kidney cells on electrodes during the cultivation or infection with herpes simplex viruses. Based on finite element simulations, a new equivalent circuit is developed for the electrical characteristics of cells on the electrode. Equivalent circuit parameters are determined from measured impedance data for both the cell/cell and cell/electrode junctions. Therefore a fitting technique based on the developed equivalent circuit model is used. The resistances of cell/cell and cell/electrode junction are decreased in accordance with multiplicity of virus infection.