Local fixation of antibiotics with fibrin spray on soft tissues: Experimental study on the relevance of the application techniques

Objective In acute and chronic infections of soft tissue, a radical surgical debridement is necessary, and is regarded as the 'Gold Standard, as well as an immediately systemic antibiotic therapy. Additional treatment with local antibiotics and/or antibiotic-containing materials is commonly used in clinical settings, but the efficient concentration of the antibiotic is not well-known. Methods Aside from the typical procedures which are provided and supported by the industry, we have conducted an animal study including 39 Sprague Dawley rats. We have treated the back sores with local antibiotics (vancomycin) alone or in two combinations with a fibrin-glue spray technique. Results It could be demonstrated that, in particular, the simultaneous application of vancomycin and fibrin leads to a stable antibiotic concentration and a long period of time wherein the antibiotic substance remains in the tissue. Conclusions This easy and inexpensive method of application can be a promising factor for the clinical improvement of local antibiotic therapy.