Cell simulation for validation of cell micrograph evaluation algorithms

The evaluation of biological microscopy experiments is a large subfield in image processing. Many methods have been published, which are specially designed for a certain microscopy technique or even for a single experiment. Usually they are evaluated with user annotated data which is prone to errors and, thus, shows inter-and intra-observer variance. We present a simulation software capable to generate micrographs with known ground truth of various microspcopy techniques for an unbiased and objective evaluation.