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1995
Conference Paper
Title
Comparative in-vitro investigations of the chemical durability of inorganic fibrous materials
Abstract
The carcinogenic risk of inorganic fibrous materials is governed by their geometrical shape and biopersistence. The latter has to be understood as the biological residence time of inhaled fibres. Different mechanisms are active which can strongly influence the biopersistance, e.g. fragtmentation, translocation, and the chemical dissolution by thew environmental body fluid. Sinde the last mechanism seems to be one of the most important, the in-vitro examination of the dissolution behaviour was established besides the usual in-vivo investigations, e.g. inhalation tests on rats. The recent literature has concentrated on the in-vitro investigatione of man made vitreous fibres (MMVF), especially of insulation wools made of glass, rocks, or slags, the carciongenic potential of which has been chemical durability of MVFF to those of craystalline fibrous materials which are assumed to have no or less carcinogenic risk, in paricular wollastonite an gypsum, and a ceramic fibre which is assumed to have high carcinogenic risk.
Language
English