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  4. Chronic Spontaneous Urticaria: The Role and Relevance of Autoreactivity, Autoimmunity, and Autoallergy
 
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2023
Review
Title

Chronic Spontaneous Urticaria: The Role and Relevance of Autoreactivity, Autoimmunity, and Autoallergy

Abstract
Chronic spontaneous urticaria (CSU) is a frequent and often severely disabling disease. A large number of studies were performed during the last 2 decades to clarify its pathogenesis. These studies shed light on the underlying autoimmune mechanisms of CSU pathogenesis and have led us to understand that different mechanisms may exist and, sometimes, coexist behind the same clinical presentation. The present article reviews the meaning of the terms autoreactivity, autoimmunity, and autoallergy, which have been variably used over the years to define different endotypes of the disease. Furthermore, we discuss the methods potentially able to lead us to the correct classification of CSU patients.
Author(s)
Asero, Riccardo
Ferrer, Marta
Kocaturk, Emek
Fraunhofer-Institut für Translationale Medizin und Pharmakologie ITMP  
Maurer, Marcus
Fraunhofer-Institut für Translationale Medizin und Pharmakologie ITMP  
Journal
The journal of allergy and clinical immunology. In practice  
DOI
10.1016/j.jaip.2023.02.022
Language
English
Fraunhofer-Institut für Translationale Medizin und Pharmakologie ITMP  
Keyword(s)
  • Autoimmunity

  • Autoreactivity

  • Chronic urticaria

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