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  4. Considerations for and Guidance to Testing and Evaluating Migration/Release of Nanoparticles from Polymer Based Nanocomposites
 
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2020
Journal Article
Title

Considerations for and Guidance to Testing and Evaluating Migration/Release of Nanoparticles from Polymer Based Nanocomposites

Abstract
The use of nanoadditives in food contact materials requires risk assessment to ensure consumers' safety. The evaluation of health risk is based on the combination of two elements: hazard and exposure. For nanomaterials (NM) used as additives in nanocomposites, the exposure is directly linked to the level of migration or release of the NM into the food. In principle, appropriate methods for experimental determination and theoretical estimation of migration are available but need diligent considerations to avoid erroneous conclusions from the measured data. We propose a comprehensive test scheme based on these methods, starting with characterization of the nanomaterial itself and when incorporated in the polymer. These data form the basis for making a decision whether migration of the NM can be excluded by migration theoretical considerations or if experimental migration testing and/or abrasion testing for mechanical release should be carried out. Guidance to and considerations for each of these steps and regarding the applicable methods are discussed. In conclusion, the results will provide a basis for risk assessment, either directly when exposure of consumers to the nanomaterials can be excluded or will be very low or, in the case of evidenced exposure, in combination with then needed toxicological data.
Author(s)
Franz, Roland  
Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV  
Bott, Johannes  
Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV  
Störmer, Angela  
Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV  
Journal
Nanomaterials  
Open Access
DOI
10.3390/nano10061113
Language
English
Fraunhofer-Institut für Verfahrenstechnik und Verpackung IVV  
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