RIFM fragrance ingredient safety assessment, propanal diethyl acetal, CAS registry number 4744-08-5

Api, A.M.; Belsito, D.; Botelho, D.; Bruze, M.; Burton, G.A.; Buschmann, J.; Dagli, M.L.; Date, M.; Dekant, W.; Deodhar, C.; Francis, M.; Fryer, A.D.; Jones, L.; Joshi, K.; Cava, S. La; Lapczynski, A.; Liebler, D.C.; O'Brien, D.; Patel, A.; Penning, T.M.; Ritacco, G.; Romine, J.; Sadekar, N.; Salvito, D.; Schultz, T.W.; Sipes, I.G.; Sullivan, G.; Thakkar, Y.; Tokura, Y.; Tsang, S.

2019

Journal Article

Abstract

There are insufficient toxicity data on the target material propanal diethyl acetal (CAS # 4744-08-5). Hence, in silico evaluation was conducted to determine read-across analogs for this material. Based on structural similarity, reactivity, metabolism data, physical-chemical properties, and expert judgment, analogs acetal (CAS # 105-57-7) and butane, 1,1'-[methylenebis(oxy)]bis- (CAS # 2568-90-3) were identified as read-across materials with sufficient data for toxicological evaluation of genotoxicity.

Author(s)

Api, A.M.

Belsito, D.

Botelho, D.

Bruze, M.

Burton, G.A.

Buschmann, J.

Dagli, M.L.

Date, M.

Dekant, W.

Deodhar, C.

Francis, M.

Fryer, A.D.

Jones, L.

Joshi, K.

Cava, S. La

Lapczynski, A.

Liebler, D.C.

O'Brien, D.

Patel, A.

Penning, T.M.

Ritacco, G.

Romine, J.

Sadekar, N.

Salvito, D.

Schultz, T.W.

Sipes, I.G.

Sullivan, G.

Thakkar, Y.

Tokura, Y.

Tsang, S.

Zeitschrift

Food and Chemical Toxicology : FCT

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RIFM fragrance ingredient safety assessment, propanal diethyl acetal, CAS registry number 4744-08-5