Radiomics Features of the Spleen as Surrogates for CT-Based Lymphoma Diagnosis and Subtype Differentiation

In malignant lymphoma an early and accurate diagnosis is essential for therapy initiation and patient outcome. Within the diagnostic process, imaging plays a crucial role in disease staging. However, an invasive biopsy is required for subtype classification. Involvement of the spleen, a major lymphoid organ, is frequent in malignant lymphoma; this may be reactive or due to infiltration by malignant cells. Using radiomics features of the spleen in a machine learning approach, we investigated the possibility of distinguishing malignant lymphoma patients from other cancer patients and to classify lymphoma subtypes in the case of disease presence. Recent studies have proven the value of radiomics analysis in differentiating lymphoma from non-lymphoma groups on involved sites. Supported by machine learning, imaging could gain importance as a noninvasive diagnostic tool for future lymphoma classification, offering more precise radiological information for an interdisciplinary approach regarding treatment planning.