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  4. Chronic inhalation toxicity and carcinogenicity of 4,4-methylenediphenyldiisocyanate (MDI) in rats
 
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1997
Journal Article
Title

Chronic inhalation toxicity and carcinogenicity of 4,4-methylenediphenyldiisocyanate (MDI) in rats

Abstract
Female Wistar rats were exposed in 6 m³ id groups and in increase in maternal lung weight in the high dose group. Consequently, a "no embryotoxic effect level" of 3 mg/m³ was determined. MDI metabolites occured in decreasing concentrations in the placenta, the fetus and the amniotic fluid. Further investigations are necessary to clarify the mechanism of the MDI-dependent tumor induction in the respiratory tract of the rat.
Author(s)
Hoymann, H.-G.
Buschmann, J.
Ernst, H.
Bartsch, W.
Creutzenberg, O.
Bellmann, B.
Dasenbrock, C.
Koch, W.
Preiß, A.
Heinrich, U.
Journal
Naunyn-Schmiedebergs archives of pharmacology  
Language
English
ITA  
Keyword(s)
  • 4,4'-methylenediphenyldiisocyanate

  • inhalation toxicology

  • rat

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