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1997
Journal Article
Title
Chronic inhalation toxicity and carcinogenicity of 4,4-methylenediphenyldiisocyanate (MDI) in rats
Abstract
Female Wistar rats were exposed in 6 m³ id groups and in increase in maternal lung weight in the high dose group. Consequently, a "no embryotoxic effect level" of 3 mg/m³ was determined. MDI metabolites occured in decreasing concentrations in the placenta, the fetus and the amniotic fluid. Further investigations are necessary to clarify the mechanism of the MDI-dependent tumor induction in the respiratory tract of the rat.