Development of Topical Formulations with Antibacterial Efficacy from Peel Extract of Mangifera indica: Emulsions and Micro-emulsions

Because some pathogenic bacteria are becoming more resistant to known antibiotics, more research into the development of new antibacterial agents is required. The main study objective was to develop several formulations containing peel extract of Mangifera indica (mango) and evaluate their antibacterial efficacy. The macerating extraction process was used to produce the mango peel extract. Cytotoxicity of the mango peel extract was also evaluated. The emulsions and microemulsions were prepared and assessed based on their appearance, phase separation, consistency, viscosity, and conductivity. The formulations were then evaluated for antibacterial and growth inhibitory effects against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus) bacteria. The findings revealed that no cytotoxic effects on skin keratinocyte cells were identified. Most formulations were physico-chemically acceptable. Only S. aureus bacteria were inhibited by emulsions and microemulsions containing mango peel extract.