• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Konferenzschrift
  4. Self-Assembled Plasmonic DNA Origami Nanoantennas for Diagnostics Applications with Low-Tech Devices
 
  • Details
  • Full
Options
2020
Conference Paper
Title

Self-Assembled Plasmonic DNA Origami Nanoantennas for Diagnostics Applications with Low-Tech Devices

Abstract
The DNA origami technique provides an unprecedented method to create multiple copies of well-defined self-assembled nanostructures.1 Methods of modern chemistry allow to functionalize DNA with molecules and functional groups of interest. Exploiting these features we designed a pillar-shaped 3D DNA origami nanostructure functionalized with biotins for the surface immobilization and docking strands allowing to precisely position plasmonic nanoparticles. Upon illumination with freely propagating light, the local electric field between nanoparticles increases and a dye placed in the plasmonic hotspot exhibits a fluorescence gain of several orders of magnitude.2 In our present work, we modified a hotspot region with molecular recognition units (molecular beacon3 or sandwich assay) to detect an enhanced signal only in the presence of a specific nucleic acid target (Figure 1).
Author(s)
Trofymchuk, Kateryna
TU Braunschweig; LMU München
Glembockyte, Viktorija
TU Braunschweig
Grabenhorst, Lennart
TU Braunschweig
Close, Cindy
TU Braunschweig
Pfeiffer, Martina
TU Braunschweig
Yadaav, Renukka
TU Braunschweig
Lalkens, Birka
TU Braunschweig
Behrendt, Vivien  
Fraunhofer-Institut für Physikalische Messtechnik IPM  
Hauer, Benedikt  
Fraunhofer-Institut für Physikalische Messtechnik IPM  
Brandenburg, Albrecht  
Fraunhofer-Institut für Physikalische Messtechnik IPM  
Acuna, Guillermo Pedro
Univ. Fribourg
Tinnefeld, Philip
LMU München
Mainwork
FNANO 2020, 17th Annual Conference on Foundations of Nanoscience. Self-Assembled Architectures and Devices  
Conference
Annual Conference on Foundations of Nanoscience (FNANO) 2020  
Link
Link
Language
English
Fraunhofer-Institut für Physikalische Messtechnik IPM  
Keyword(s)
  • Nanoantennas

  • Diagnostics Applications

  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024