Resveratrol-loaded polycaprolactone scaffolds obtained by rotary jet spinning

The production of scaffolds has proved a solid option in bioengineering aimed at tissue neoformation due to their characteristics that favor cell recruitment and proliferation and may even provide the necessary mechanical characteristics during tissue reestablishment phases. Several combinations have been proposed in the manufacture of biomaterials, such as the association of components that can increase or enhance their action on the host tissue. This work aimed to produce and evaluate in vitro composite scaffolds composed of the polymer polycaprolactone and the polyphenol resveratrol, produced by the rotary jet spinning process, as a bone grafting material, envisioning future uses in tissue engineering. The following samples were produced: polycaprolactone scaffold (control), polycaprolactone scaffolds with resveratrol at 1%, 3%, and 5%. Morphological evaluation under scanning electron microscopy evidenced that the produced scaffolds have fibers with random distribution, diameters, and porosities that can favor cell migration and adhesion. The in vitro analyses showed that the samples have a similar behavior to control in the 24-h period and that the PCL/RESV 5% scaffold provided cell growth over time in the 72-h evaluation since PCL is a polymer with consolidated use in the production of biomaterials and the scaffolds proved promising in carrying phytotherapy medicines.