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1997
Book Article
Titel
Molecular approaches to glutathione biosynthesis
Abstract
The thiol tripeptide glutathione is synthesized in plants from the constituent amino acids in two enzyme catalyzed reaction steps. The properties and the regulation of both enzymes, namely gamma-glutamyl-cysteine synthetase (EC 6.3.2.2) and glutathione synthetase (EC 6.3.2.3), have been analyzed by classical biochemical studies and, recently, by plant molecular biology techniques. In the present review, the results achieved by these approaches are compared and a preliminary scheme for the regulation of cytosolic glutathione levels in plants is suggested with special emphasis on the interaction between the pathways of assimilatory sulphate reduction and glutathione biosynthesis.