• English
  • Deutsch
  • Log In
    Password Login
    Research Outputs
    Fundings & Projects
    Researchers
    Institutes
    Statistics
Repository logo
Fraunhofer-Gesellschaft
  1. Home
  2. Fraunhofer-Gesellschaft
  3. Scopus
  4. Encapsulation of Nanoparticles with Statistical Copolymers with Different Surface Charges and Analysis of Their Interactions with Proteins and Cells
 
  • Details
  • Full
Options
2024
Journal Article
Title

Encapsulation of Nanoparticles with Statistical Copolymers with Different Surface Charges and Analysis of Their Interactions with Proteins and Cells

Abstract
Encapsulation with polymers is a well-known strategy to stabilize and functionalize nanomaterials and tune their physicochemical properties. Amphiphilic copolymers are promising in this context, but their structural diversity and complexity also make understanding and predicting their behavior challenging. This is particularly the case in complex media which are relevant for intended applications in medicine and nanobiotechnology. Here, we studied the encapsulation of gold nanoparticles and quantum dots with amphiphilic copolymers differing in their charge and molecular structure. Protein adsorption to the nanoconjugates was studied with fluorescence correlation spectroscopy, and their surface activity was studied with dynamic interfacial tensiometry. Encapsulation of the nanoparticles without affecting their characteristic properties was possible with all tested polymers and provided good stabilization. However, the interaction with proteins and cells significantly depended on structural details. We identified statistical copolymers providing strongly reduced protein adsorption and low unspecific cellular uptake. Interestingly, different zwitterionic amphiphilic copolymers showed substantial differences in their resulting bio-repulsive properties. Among the polymers tested herein, statistical copolymers with sulfobetaine and phosphatidylcholine sidechains performed better than copolymers with carboxylic acid- and dimethylamino-terminated sidechains.
Author(s)
Megahed, Saad
Wutke, Nicole
Liu, Yang
Klapper, Markus
Schulz, Florian
Feliu Torres, Neus  
Fraunhofer-Institut für Angewandte Polymerforschung IAP  
Parak, Wolfgang Johann
Journal
International journal of molecular sciences  
Open Access
DOI
10.3390/ijms25105539
Additional full text version
Landing Page
Language
English
Fraunhofer-Institut für Angewandte Polymerforschung IAP  
Keyword(s)
  • amphiphilic polymers

  • cellular uptake

  • nanoparticles

  • protein corona

  • Cookie settings
  • Imprint
  • Privacy policy
  • Api
  • Contact
© 2024