Immunosensing by centrifugally automated surface plasmon resonance detection based on a smartphone camera

This paper reports centrifugal microfluidic automation of surface plasmon resonance (SPR) detection of a protein concentration series (IgG). Using event-triggered rotational flow control based on water-dissolvable film (DF) valving, blood separation, metering, incubation and washing steps were parallelized on an integrated ""Lab-on-a-Disc"" (LoaD) cartridge. In a prism-based coupling scheme, the change in the angle of minimum reflectivity due to specific biomolecular binding was measured by a conventional smartphone camera.