Sensitivity enhanced glucose sensing by return-path Mueller matrix ellipsometry

Diabetes is a worldwide public health problem. According to the survey of the Robert Koch Institute, in Germany, at least 7.2 percent population (aged between 18 to 79 years) have diabetes. Therefore, the demand for glucose monitoring is increasing, especially for non-invasive glucose monitoring technology. In this work, we proposed a novel method to enhance the sensitivity of glucose monitoring by return-path ellipsometry with a quarter-wave plate and mirror. The coaxial design improves the sensitivity and reduces the complexity of optical system alignment by means of a fixed quarter-wave plate. The proposed system showed higher sensitivity compared to the transmission configuration.