A CMOS-Based Electrochemical DNA Hybridization Microarray for Diagnostic Applications with 109 Test Sites

A 3 × 6 mm 2 CMOS DNA hybridization microarray chip is presented with 109 test sites. DNA hybridization is revealed by a decreasing cyclic voltammetry response at the respective test sites following the displacement of DNA signal oligo strands in case of successful matching and binding between PCR product and signal oligos. Each test site is equipped with a first order sigma-delta modulator providing an SNDR of 40 dB within a full scale range of +/- 16 nA. The entire chip is equipped with a user-friendly SPI Interface. Experiments with biological content demonstrate proper functionality.