Opening of new synthetic routes using segmented microflow in multistep syntheses

The application of microfluidics in organic chemistry is a valuable tool to access new synthesis pathways and to break limitations set by traditional batch chemistry. In the past, the majority of research focused on solving problems associated with individual reactions. It is necessary to advance the field by incorporating flow chemistry in longer multistep syntheses to open more direct paths towards complicated compounds. Several strategies were developed to meet the demands of a four step synthesis, which includes biphasic nitrations, gaseous substrates and very fast reactions on multifunctional molecules. A unique micro flow setup was applied in each reaction to meet its' specific requirements.