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  4. Analyses of exhaled breath condensate cytokines for identification of lung cancer
 
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2017
Journal Article
Titel

Analyses of exhaled breath condensate cytokines for identification of lung cancer

Abstract
Early non-invasive detection of lung cancer is a precondition for enabling better prognosis supported by new innovative therapy regimes. The aim of our study was to evaluate angiogenic and inflammatory proteins in exhaled breath condensate (EBC) as markers for lung cancer. Our report presents a diagnostic study of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and tumor necrosis factor-α (TNF-α) in EBC of 300 individuals, 84 patients with lung cancer, 111 patients with stable chronic obstructive pulmonary disease (COPD), and in 105 healthy controls. Detection of VEGF and bFGF in EBC was applicable to discriminate cancer patients from COPD patients as well as from healthy volunteers. Especially VEGF seems to be suitable to discriminate between non-small cell lung cancer (NSCLC) patients and control groups with highest VEGF values in EBC of patients with progressive NSCLC. The concentration of angiogenic factors correlated with disease progression as well as higher tumor stage. This study supports cytokine analysis in EBC as a suitable noninvasive diagnostic screening method for lung cancer detection and monitoring.
Author(s)
Gessner, Christian
Universität Leipzig
Ruschpler, Peter
POIS Leipzig GbR
Fricke, Stephan
Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Gillissen, Adrian
Kreiskliniken Reutlingen, Bad Urach
Hoheisel, Gerhard B.
Praxis für Pneumologie/Allergologie, Leipzig
Lehmann, Jörg
Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Sack, Ulrich
Universität Leipzig
Zeitschrift
Laboratoriumsmedizin = Journal of laboratory medicine
Thumbnail Image
DOI
10.1515/labmed-2017-0054
Language
English
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Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Tags
  • angiogenesis

  • bead array

  • cytokine

  • exhaled breath condensate

  • lung cancer

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