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  4. Bidirectional Bioelectronic Interfaces: System Design and Circuit Implications
 
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2020
Journal Article
Title

Bidirectional Bioelectronic Interfaces: System Design and Circuit Implications

Abstract
The total economic cost of neurological disorders exceeds £100 billion per annum in the United Kingdom alone, yet pharmaceutical companies continue to cut investments due to failed clinical studies and risk [1]. These challenges motivate an alternative to solely pharmacological treatments. The emerging field of bioelectronics suggests a novel alternative to pharmaceutical intervention that uses electronic hardware to directly stimulate the nervous system with physiologically inspired electrical signals [2]. Given the processing capability of electronics and precise targeting of electrodes, the potential advantages of bioelectronics include specificity in the time, method, and location of treatment, with the ability to iteratively refine and update therapy algorithms in software [3]. A primary disadvantage of the current systems is invasiveness due to surgical implantation of the device.
Author(s)
Liu, Yan
Urso, Alessandro
Martins da Ponte, Ronaldo
Costa, Tiago
Valente, Virgilio
Giagka, Vasiliki  
Serdijn, Wouter A.
Constandinou, Timothy G.
Denison, Timothy
Journal
IEEE Solid state circuits magazine  
DOI
10.1109/MSSC.2020.2987506
Language
English
Fraunhofer-Institut für Zuverlässigkeit und Mikrointegration IZM  
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