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  4. Human biomonitoring of pyrethrum and pyrethroid insecticides used indoors
 
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2003
Journal Article
Title

Human biomonitoring of pyrethrum and pyrethroid insecticides used indoors

Title Supplement
Determination of the metabolites E-cis/trans-chrysanthemumdicarboxylic acid in human urine by gas chromatography-mass spectrometry with negative chemical ionization
Abstract
This work describes a gas chromatographic-mass spectrometric method employing negative chemical ionization (NCI) for the determination of E-cis/trans-chrysanthemumdicarboxylic acid (CDCA) in human urine used as a biomarker for the exposure to pyrethrum and/or certain pyrethroids in insecticide formulations applied indoors. Mixed-mode solid phase extraction was utilized for sample cleanup. Extraction recoveries ranged from 92 to 104% (2-9% R.S.D.). The acids were esterified with 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) allowing both their gas chromatographic separation and their sensitive mass spectrometric detection under NCI conditions. Detection limits of ca. 0.05 small mu, Greekg/l urine were achieved.
Author(s)
Elflein, L.
Berger-Preiss, E.
Preiss, A.
Elend, M.
Levsen, K.
Wünsch, G.
Univ. Hannover, Inst. für Anorganische Chemie
Journal
Journal of chromatography. B  
DOI
10.1016/S1570-0232(03)00566-X
Language
English
Fraunhofer-Institut für Toxikologie und Experimentelle Medizin ITEM  
Keyword(s)
  • derivatization

  • GC

  • Pyrethrum

  • pyrethroid insecticide

  • Chrysanthemumdicarboxylic acid

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