Co-recombinogenic and co- or anti-mutagenic effects of non-genotoxic carcinogens in S. cerevisiae MP1

Carcinogens are generally classified into two groups: genotoxic and non-genotoxic. As the final product of genotoxic and non-genotoxic carcinogens is the same, that is, a clone of genetically altered cells, it could be possible that non-genotoxic carcinogens may yield genotoxic events as a secondary result of cell toxicity having led to mitogenesis/cellular proliferation, or that genetic alterations are induced that are normally neglected in genotoxcicity tests. A genetic effect with possible relevance for the ultimate mechanism of carcinogenicity is recombination. In previous experimemts using yeast, bacteria, Drosophila or mice, tumor promoters were co-recombinogenic/anti-recombinogenic. (Abstract truncated)