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  4. RNAs everywhere: Genome-wide annotation of structured RNAs
 
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2007
Journal Article
Titel

RNAs everywhere: Genome-wide annotation of structured RNAs

Abstract
Starting with the discovery of microRNAs and the advent of genome-wide transcriptomics, non-protein-coding transcripts have moved from a fringe topic to a central field research in molecular biology. In this contribution we review the state of the art of "computational RNomics", i.e., the bioinformatics approaches to genome-wide RNA annotation. Instead of rehashing results from recently published surveys in detail, we focus here on the open problem in the field, namely (functional) annotation of the plethora of putative RNAs. A series of exploratory studies are used to provide non-trivial examples for the discussion of some of the difficulties.
Author(s)
Backofen, Rolf
Universität Freiburg
Bernhart, Stephan H.
Universität Wien
Flamm, Christoph
Universität Wien
Fried, Claudia
Universität Leipzig
Fritzsch, Guido
Universität Leipzig
Hackermüller, Jörg
Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Hertel, Jana
Universität Leipzig
Hofacker, Ivo L.
Universität Wien
Missal, Kristin
Universität Leipzig
Mosig, Axel
Max-Planck-Institut für Mathematik in den Naturwissenschaften Leipzig
Prohaska, Sonja J.
Arizona State Univeristy Phoenix
Rose, Dominic
Universität Leipzig
Stadler, Peter F.
Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Tanzer, Andrea
Universität Leipzig
Washietl, Stefan
Universität Wien
Will, Sebastian
Universität Freiburg
Zeitschrift
Journal of experimental zoology. Part B, Molecular and developmental evolution
Thumbnail Image
DOI
10.1002/jez.b.21130
Language
English
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Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Tags
  • small RNA

  • mRNA

  • RNA

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