Patent
Title

Humanes rekombinantes Interferon-beta mit verbesserter Loeslichkeit

Other Title
New mutated recombinant human interferon-beta protein contains hydroxylic amino acid substitutions to improve water solubility - used e.g. in in vitro screening assays, to measure interferon levels and to treat multiple sclerosis.
Abstract
A mutated recombinant human interferon- beta protein (I) in which an amino acid having at least one hydroxy group is substituted for at least one of Leu5, Phe8, Phe15, Leu47, Phe50, Leu106, Phe111, Leu116, Leu120 and Phe156, is new. USE - (I) is used in medicaments e.g. for treating multiple sclerosis, for in vitro screening assays and for measurement of interferon levels (claimed). ADVANTAGE - The mutated protein is more water-soluble than recombinant wild-type human interferon- beta .
Inventor(s)
Otto, Bernd  
Waschuetza, G.  
Schneider-Fresenius, C.  
Link to:
Patent Number
1997-19717864
Publication Date
2001
Language
German