Metallhaltige Ribonukleotidpolypeptide

New copper-containing ribonucleoproteins are ternary complexes of an S100 protein, copper ions, and RNA comprising the following consensus sequence or its complement: GGAAAAUNNNNNUNAUAUGN1-6CUNNNUUUNNNNNNAAAAN0- 1UANAAACAUN0-5CUUNAGN0-13AGAAAUN0-16UUAGCAG where N = G, A, U or C. Also claimed is an antibody directed against a ribonucleoprotein as above. USE - The ribonucleoproteins are stated to have the following properties [no data given]: (1) ''cell-selective morphogenic action in vitro on isolated primary and/or cloned blood capillary endothelial cells in culture for the non-mitogenic induction of the change in cell phenotype from the confluent state, for non-mitogenic alteration of the spatiotemporal supracellular organisation of cells into three-dimensional organoid, capillary-like structures in culture''; (2) a specific chemotropic action on blood vessels in vivo; (3) induction of directional growth of blood vessels in vivo; and (4) induction of neovascularisation of tissues thro ugh directed ingrowth of blood vessels. Their use for modulating angiogenesis is claimed.