RITA - Registry of Industrial Toxicology Animal data. Progress of the working group

A data base for the collection of histopathological diagnoses of neoplastic and pre-neoplastic lesions and related data from control animals involved in long-term carcinogenicity or toxicity studies has been operated since 1988. Factors which may have an influence on the spontaneous tumor rate are integrated in the data base. Systematized nomenclature and standardized diagnostic criteria have been established as well as the applied data acquisition and data validation procedure.