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Isoliertes naturidentisches Kollagen

Isolating collagen useful for biomatrix production comprises isolating collagen-containing fibers from tissue and extracting collagen from the fibers with an aqueous urea solution
 
: Xiong, X.; Mertsching, H.; Rupp, S.; Brunner, H.

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DE 102006026591 A: 20060531
DE 102006026591 A: 20060531
C07K0014
C12N0005
A61L0027
G01N0033
German
Patent, Electronic Publication
Fraunhofer IGB ()

Abstract
(A1) Die vorliegende Erfindung betrifft isoliertes Kollagen, Verfahren zur Herstellung und Isolierung des Kollagens aus kollagenhaltigem Gewebe sowie die Verwendung des isolierten Kollagens in einer Biomatrix, als In-vitro-Testsystem, Gewebeersatz oder Organersatz.

 

DE 102006026591 A1 UPAB: 20080102 NOVELTY - Isolating collagen from tissue comprises isolating collagen-containing fibers from the tissue, extracting collagen from the fibers by incubation with a 5-15 M aqueous urea solution, and separating the extract from fiber and tissue residues. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are also included for: (1) isolated collagen produced as above; (2) producing a biomatrix by isolating collagen as above, separating urea by gradient dialysis, renaturing the collagen, mixing the resulting collagen solution with a cell culture medium in 2:1 to 1:2 ratio, and gelling the mixture at elevated temperature; (3) biomatrix produced as above; (4) tissue or organ replacement comprising vital tissue cells cultured in or on a biomatrix as above; (5) in-vitro test system comprising vital cells cultured in or on a biomatrix as above. USE - The collagen is useful in biomatrices for producing tissue or organ replacements or in-vitro test systems (claimed). ADVANTAGE - The collagen is largely nature-identical.

: http://publica.fraunhofer.de/documents/N-70616.html