Li, M.M.LiMiller, K.K.MillerJoldes, G.R.G.R.JoldesKikinis, R.R.KikinisWittek, A.A.Wittek2022-03-052022-03-052016https://publica.fraunhofer.de/handle/publica/24584410.1002/cnm.27712-s2.0-84960938513Patient-specific biomechanical models have been advocated as a tool for predicting deformations of soft body organs/tissue for medical image registration (aligning two sets of images) when differences between the images are large. However, complex and irregular geometry of the body organs makes generation of patient-specific biomechanical models very time-consuming. Meshless discretisation has been proposed to solve this challenge. However, applications so far have been limited to 2D models and computing single organ deformations. In this study, 3D comprehensive patient-specific nonlinear biomechanical models implemented using meshless Total Lagrangian explicit dynamics algorithms are applied to predict a 3D deformation field for whole-body image registration.enjournal article