Bauer, J.J.BauerKinast, S.S.KinastBurger-Kentischer, A.A.Burger-KentischerFinkelmeier, D.D.FinkelmeierKleymann, G.G.KleymannRayyan, W.A.W.A.RayyanSchröppel, K.K.SchröppelSingh, A.A.SinghJung, G.G.JungWiesmüller, K.-H.K.-H.WiesmüllerRupp, S.S.RuppEickhoff, H.H.Eickhoff2022-03-042022-03-042011https://publica.fraunhofer.de/handle/publica/22646810.1021/jm200571eNovel nontoxic (S)-2-aminoalkylbenzimidazole derivatives were found to be effective against Candida spp. at low micromolar concentrations using high-throughput screening with infected HeLa cells. A collection of analogues defined the chemical groups relevant for activity. The most active compound was characterized by transcriptional analysis of the response of C. albicans Sc5314. (S)-2-(1-Aminoisobutyl)-1-(3-chlorobenzyl)benzimidazole had a strong impact on membrane biosynthesis. Testing different clinically relevant pathogenic fungi showed the selectivity of the antimycotic activity against Candida species.en660615journal article