Under CopyrightSfakianakis, S.S.SfakianakisGraf, N.N.GrafHoppe, A.A.HoppeRüping, StefanStefanRüpingWegener, DennisDennisWegenerKoumakis, L.L.Koumakis2022-03-1118.8.20092009https://publica.fraunhofer.de/handle/publica/36251310.24406/publica-fhg-362513The analysis of clinico-genomic data poses complex computa- tional problems. In the project ACGT, a grid-based software system to sup- port clinicians and bio-statisticians in their daily work is being developed. Starting with a detailed user requirements analysis, and with the continu- ous integration of usability analysis in the development process, the project strives to develop an architecture that will substantially improve the way clinico-genomic trials are conducted today. In this paper, results of the ini- tial requirements analysis and approaches to address these requirements are presented. We also discuss the importance of appropriate metadata to tailor the system to the needs of the users.en005006629conference paper